The history of aspartame dates back to 1965 when the lowcalorie sweetener was accidentally discovered by chemist james schlatter. The institute tied to pd investigated by the american congress. Efsa acknowledged improvements in design of the scientific study. Aspartame induces lymphomas and leukaemias in rats. A questo punto report introduce il parere dellistituto di ricerche oncologiche ramazzini, secondo il quale le dosi calcolate dallefsa vanno. In a previous study conducted at the cesare maltoni cancer research center of the european ramazzini foundation cmcrcerf, we demonstrated for the first time that aspartame apm is a multipotent carcinogenic agent when various doses are administered with feed to spraguedawley rats from 8 weeks of age throughout the life span. Before the study even began, it was revealed that efsa had hired scientists linked to the food industry to perform the research. In its opinion, the panel concluded, on the basis of all the evidence currently available, that there is no need. There are three epidemiologic studies that were published after 2009. Morando soffritti of the european ramazzini foundation will present the results of a new study confirming the carcinogenicity of aspartame on april 23, 2007 at the mount sinai medical school of new york, where he also will receive the prestigious irving j. So when they released the studies showing aspartame to be a multipotential carcinogen industry fought to convince the public not to accept them by saying the rats had respiratory disease. This statement further confirms efsas 2006 statement regarding an earlier ramazzini study, which alleged that aspartame consumption may cause cancer. The most recent official attempt to settle the controversy was provided by the european food safety authoritys or efsa panel on food additives and nutrient sources added to food or ans in december 20. In 2005, the european ramazzini foundation published important experimental data demonstrating the carcinogenicity of aspartame.
The european food safety authoritys efsa s ans panel adopted an opinion on this study in january 2009. Given the shortcomings of efsas risk assessment of aspartame, and the. Aspartame, updated assessment of risks on health, cancer and pregnancy context aspartame is one of the most widely used artificial sweetener, is it safe. Aspartame, updated assessment of risks on health, cancer and. Erf stands behind aspartame study results, announces ongoing research on artificial sweeteners. It is a white, odourless powder, approximately 200 times sweeter than sugar. Jun 24, 2006 scientific director of the european ramazzini foundation and primary author of the aspartame study, dr. Efsa assesses new aspartame study and reconfirms its safety the afc panel of the european food safety authority efsa has evaluated the new longterm study on the carcinogenicity of aspartame conducted by the european ramazzini foundation in bologna, italy. Aspartame and its breakdown products have been the subject. Food safety authority says aspartame not linked to cancer. In may 2011, efsa was asked by the european commission to bring forward the full reevaluation of the safety of aspartame e 951, which was previously.
Ramazzini study on radiofrequency cell phone radiation. So, the ramazzini studies confirmed aspartame as a multipotential carcinogen. Dec 10, 20 aspartame and its breakdown products are safe for human consumption at current levels of exposure, efsa concludes in its first full risk assessment of this sweetener. A novel innovative device for qualitative estimation of glucose, protein. New results on glyphosate danger from the ramazzini. The ramazzini foundation however is refusing to close the book on aspartame.
The studies in which tumor responses were reported were all conducted by the european ramazzini foundation on oncology and. In efsa s 20 scientific opinion of the safety of aspartame, the authority concluded that aspartame and its breakdown products pose no toxicity concern for consumers at current levels of exposure. Ramazzini institutes second study confirms aspartame. New study by ramazzini institute confirms aspartame. This is my work, i am the author and i own the to the work. In europe, it is authorised to be used as a food additive in foodstuffs such as drinks, desserts, sweets, dairy, chewing gums, energyreducing and weight control products and as a tabletop sweetener. Aspartame is an intense, lowcalorie, artificial sweetener. The carcinogenicity studies of the ramazzini institute on apm shown.
Amongst food additives, aspartame is one of the most controversial, especially in the usa, but also in the uk and the eu. These data demonstrated for the first time that aspartame is a carcinogenic agent, inducing various types of malignant tumors in rats, even at dose levels currently considered acceptable for humans. First experimental demonstration of the multipotential. Although efsa found many problems with the ramazzini study, the panel stated that one of the reasons for the confounding conclusions by ramazzini may be due, in part, to the fact that the rats. Jan 17, 2017 this statement further confirms efsas 2006 statement regarding an earlier ramazzini study, which alleged that aspartame consumption may cause cancer.
In previous evaluations by jecfa and the scf, an adi of 40 mgkg bwday was established based on chronic toxicity in animals. Aspartame is currently used in a variety of food and beverage items, such as yogurt, desserts and carbonated drinks. The problem is that when efsa asks them erf to elaborate on. Aspartame study regarding ramazzini study, which looked at long term exposure to aspartame through feed in mice, efsa identified several flaws in its design.
Efsa confirms safety of sucralose, rejecting findings of ramazzini institute. Il gruppo di esperti ha valutato gran parte dei dati emersi dal nuovo studio sull aspartame forniti allefsa dalla fondazione europea ramazzini. Jan 08, 20 the european food safety authority efsa has today launched a public consultation on its draft scientific opinion on the safety of the artificial sweetener aspartame. The panel also said there was no risk to the developing foetus from aspartame consumption, and that aspartame does not harm the brain, nervous system or cognitive function in. Scientific director of the european ramazzini foundation and primary author of the aspartame study, dr. Efsa noted numerous issues with the ramazzini institute study on sucralose, including. In an article published in the march 2006 issue of environmental health perspectives ehp soffritti et al. Lack of potential carcinogenicity for aspartame systematic. This is a faithful summary of the leading report produced in 20 by the european food safety authority efsa.
Jun, 2011 the commission pressed efsa to carry out a fresh risk assessment of the sweetener immediately in the wake of growing concern among meps and others about its effect on. European food safety authority slams ramazzini study, finds. The efsa panel on food additives and nutrient sources added to food ans considered for its assessment the publication from soffritti et al. More than 10 years ago, the ramazzini institute signed a research according to which aspartame would be carcinogenic. The same european food safety authority intervened. I explicitly give efsa permission to exchange the book chapter i attach to this email with the joint faowho expert committee on food additives. Overall findings continue to support lack of carcinogenicity from aspartame consumption. Scientific opinion on the reevaluation of aspartame e 951 as a food. Ramazzini set to publish new pathology slides aspartame study. The european food safety authority efsa said it considers carefully any new evidence that was not available at the time an opinion is adopted. Fresh fears raised about aspartame society the guardian. Efsa completes full risk assessment on aspartame and.
Initially, the ramazzini authors chose not to fulfill efsa s data request. This is also a continuation of my official submission to the efsa call for data on aspartame on the 7th of july, 2011. The new ramazzini study, like the first, allows rats to live out their natural life rather than. Its director, dr morando soffritti, told journalists at the rome conference that it stands by its research finding that. The study is currently being published in the european journal of oncology and final results will be presented at the 3rd international scientific conference of the collegium ramazzini, framing the future in light of the past. One promising example of such novel methods is known as syrcle. Efsa confirms safety of sucralose, rejecting findings of. Worlds largest animal study on cell tower radiation confirms cancer link scientists call on the world health organization international agency for research on cancer to reevaluate the carcinogenicity of cell phone radiation after the ramazzini institute and us government studies report finding the same unusual cancers. Adding it does not consider it appropriate to suggest any change in consumers diets relative to aspartame on the basis of the information it currently has. After the evaluation of data from required studies, the u.
The european food safety authority efsa commenced a reevaluation of aspartame as part of the systematic reevaluation of all food additives authorised in the eu prior to 20 january 2009. The artificial sweetener aspartame has been the subject of several controversies since its initial. The results of this study will be presented april 23, 2007 at the mount sinai medical school of new york, where erf scientific director morando soffritti will receive the third irving j. Lifespan exposure to low doses of aspartame beginning during. Apm was administered with feed to 8weekold spraguedawley rats 100150sexgroup, at concentrations of 100,000, 50,000, 10,000, 2,000, 400, 80, or 0 ppm. In particular the scientists said the length of the study meant that erroneous conclusions could be drawn.
Risk communication, media amplification and the aspartame. Results of study on the carcinogenicity of the artificial. Efsa was aware of the upcoming study of the ramazzini foundation on aspartame and had requested detailed information from them. She said the ramazzini institute had released several studies over the past few years and efsa had an obligation to look at them. The cesare maltoni cancer research center of the european ramazzini foundation of oncology and. Scientific opinion on the reevaluation of aspartame e 951.
The european ramazzini foundation erf animal cancer studies on aspartame. Aspartame induces lymphomas and leukaemias in rats soffritti et al. Living in a chemical world, to be held in bologna, italy from september 1821, 2005. The efsa ans panel provides a scientific opinion on the safety of aspartame e 951. Moreover, the ramazzini institute was doubted of not having used international standards. In its opinion, the panel concluded, on the basis of all the evidence. Scientists at the ramazzini foundation found that when administered to rats for their entire life span, aspartame, an artificial sweetener used in more than 6,000 food and pharmaceutical products, induces an increase in lymphomas and. In contrast, studies conducted in the 1970s by, or under.
Mission possible world health international 9270 river club parkway duluth, georgia 30097 telephone. The molecule breaks down to diketopiperazine, a tumor agent. European food safety authority confirms sucralose is safe and does. Aspartame induces lymphomas and leukaemias in rats request pdf. The report was issued by the efsa panel on food additives and nutrient sources added to food ans, and basically said that the data supplied by the ramazzini foundation in a paper by soffritti.
European food safety authority efsa to assess the erf aspartame carcinogenicity study. Efsa has reported that the results of the ramazzini institute studies do not change its conclusions regarding the noncarcinogenicity of aspartame efsa, 2009, 20. Apr 17, 2007 new study by ramazzini institute confirms aspartame carcinogenic. Food and drug administration approved aspartame for use in certain foods in 1981, soft drinks in 1993, and authorized aspartame as a generalpurpose sweetener for foods and beverages in 1996. Aspartame should receive the lowest possible priority for.
In april 2017, the european food safety authoritys efsa scientific panel on food additives and nutrient sources added to food ans discussed the 2016 publication by soffritti et al. Publication will reignite the aspartame debate after the european food safety authority efsa dismissed the first ramazzini rat study, saying there was no dose response in the experiment and that the rats were sick with pulmonary infections. Aspartame is a sweetener authorised as a food additive in the eu. Dopo aver valutato i risultati del nuovo studio sullaspartame. A second study conducted by the european ramazzini foundation erf confirms the carcinogenicity of aspartame. Nov 17, 2005 the cesare maltoni cancer research center of the european ramazzini foundation has conducted a longterm bioassay on aspartame apm, a widely used artificial sweetener. European food safety authority slams ramazzini study. May 15, 2006 the ramazzini foundation however is refusing to close the book on aspartame. Efsa assesses new aspartame study and reconfirms its safety. In efsas 20 scientific opinion of the safety of aspartame, the authority concluded that aspartame and its breakdown products pose no toxicity concern for consumers at current levels of exposure. Likewise, in 2007, the fda concluded, it finds no reason to alter its previous conclusion that aspartame is safe as a general purpose sweetener in food u.
In 2007 the european ramazzini foundation in bologna, italy, published findings of a new study on the carcinogenicity of aspartame in rats. Herman koeter, efsa acting executive director, efsa considers that the results of this new study on aspartame by ramazzini researchers do not provide. European food safety authority efsa, 20, the results of the studies performed by soffritti et al. The afc panel of the european food safety authority efsa has evaluated the new longterm study on the carcinogenicity of aspartame conducted by the ramazzini institute. Results of study on the carcinogenicity of the artificial sweetener aspartame.
The european food safety authority efsa has been asked by the european commission to assess the carcinogenicity study performed by the european ramazzini foundation of oncology and environmental sciences erf on the artificial sweetener aspartame, which was reported in publications in 2005 and 2006. In may 2011, the european food safety authority efsa accepted a request from the european commission for the reevaluation of the safety of aspartame in 2012. Overwhelming scientific evidence confirms aspartame safety. The european food safety authority efsa commenced a reevaluation of aspartame as part of the systematic. Herman koeter who was head of the committee resigned and said. The aspartame industry really fears the ramazzini institute because they are world renowned for cancer research. Efsa has rejected their aspartame studes twice here and here and the epa wont use them either. It is based on this rationale that the european ramazzini foundation performed a megaexperiment on 1,800 rats and demonstrated that, in our experimental conditions, aspartame is a multipotential carcinogenic agent soffritti et al. Quali sono i lavori recenti svolti dallefsa sullaspartame e quali studi ha preso. Dubious efsa announcement of aspartame safety saturates.
The first ramazzini study on aspartame, published in 2005, used 1800 rats. Industry did everything they could to get the european food safety authority, efsa, not to accept them. The efsa panel requested information from the authors of the ramazzini studies to assist in its evaluation. The current adi for aspartame is deemed to be safe for the general population. European food standards agency efsa blesses aspartame. Sep 23, 2008 on 14 july 2005, the ramazzini foundation held a press conference on the cancer risks posed by the sweetener aspartame, which received worldwide media attention. The ramazzini institute used a lifetime model of their own design that has been.
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